Flygut: an atlas of the Drosophila adult midgut

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Gene name CSN4
Flybase description The gene COP9 complex homolog subunit 4 is referred to in FlyBase by the symbol Dmel\CSN4 (CG8725, FBgn0027054).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.0992 -1.2096 -1.501053 -1.5731 -1.910195 -1.8827 -1.77611 -1.679237
    Affimetrix absolute value 8.275 7.35 7.594 7.736 7.826 7.659 7.728 7.501
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; transcription regulatory region DNA binding; NEDD8 activating enzyme activity.
There is experimental evidence that it is involved in the biological process: protein deneddylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; compound eye photoreceptor cell differentiation; lateral inhibition; protein stabilization; mitotic cell cycle G2/M transition DNA damage checkpoint.
8 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; cephalopharyngeal skeleton; photoreceptor cell; mesothoracic tergum.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Proteasome component (PCI) domain; Tetratricopeptide-like helical; Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.
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