Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Six4
Flybase description The gene Six4 is referred to in FlyBase by the symbol Dmel\Six4 (CG3871, FBgn0027364).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -30.305 -15.6505 -22.520959 -23.3373 -34.309142 -30.6368 -35.19701 -22.272941
    Affimetrix absolute value 3.488 3.692 3.7 3.847 3.673 3.633 3.419 3.815
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: myoblast fusion; gonad development; fat body development; mesoderm development.
10 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; multicellular structure; anatomical structure; embryonic/larval hypodermal muscle; adult; muscle system; organ system subdivision; late extended germ band embryo; extended germ band embryo; germline cell; embryonic/larval somatic muscle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed within 00-06 hour embryonic stages.
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