Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CHES-1-like
Flybase description The gene Checkpoint suppressor homologue is referred to in FlyBase by the symbol Dmel\CHES-1-like (CG12690, FBgn0029504).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.6534 0.4104 -1.711998 -1.3326 -3.667179 -1.6855 -0.78575 -3.409748
    Affimetrix absolute value 7.01 7.717 7.427 7.999 6.92 7.811 8.067 6.633
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: cellular response to hypoxia; mitotic cell cycle G1/S transition DNA damage checkpoint; phagocytosis, engulfment.
30 alleles are reported.
The phenotypes of these alleles are annotated with: eye; heart primordium.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Armadillo-like helical; Transcription factor, fork head; Transcription factor, fork head, conserved site; Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
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