Flygut: an atlas of the Drosophila adult midgut

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Gene name Nep1
Flybase description The gene Neprilysin 1 is referred to in FlyBase by the symbol Dmel\Nep1 (CG5905, FBgn0029843).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -49.2323 -20.5813 -24.235449 -27.8016 -3.796188 -1.5619 -31.33861 -5.02269
    Affimetrix absolute value 2.789 3.269 3.607 3.598 6.834 7.933 3.689 5.988
    Affymetric present call in "x" number of chips 0 0 0 0 3 3 1 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: metallopeptidase activity; metalloendopeptidase activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: proteolysis.
7 alleles are reported.
The phenotype of these alleles is annotated with: wing.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Metallopeptidase, catalytic domain; Peptidase M13; Peptidase M13, neprilysin; Peptidase M13, neprilysin, C-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
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