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| Gene name | Dok | ||||||||||||||||||||||||||||||||||||
| Flybase description | The gene Downstream of kinase is referred to in FlyBase by the symbol Dmel\Dok (CG2079, FBgn0029944). | ||||||||||||||||||||||||||||||||||||
| Expression data along the gut |
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| Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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| Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: insulin receptor binding. There is experimental evidence that it is involved in the biological process: dorsal closure, elongation of leading edge cells; dorsal closure; stress-activated protein kinase signaling cascade; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: orbital bristle; interommatidial bristle; chaeta; heart primordium; wing; thorax. It has one annotated transcript and one annotated polypeptide. Protein features are: Insulin receptor substrate-1, PTB; Pleckstrin homology domain; Pleckstrin homology-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. . |
