Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Tsp
Flybase description The gene Thrombospondin is referred to in FlyBase by the symbol Dmel\Tsp (CG11326, FBgn0031850).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -31.9536 -17.015 -21.902522 -28.1338 -35.841651 -36.8761 -36.34826 -22.972123
    Affimetrix absolute value 3.455 3.616 3.761 3.574 3.608 3.365 3.374 3.804
    Affymetric present call in "x" number of chips 0 1 1 1 0 1 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: heparin binding.
There is experimental evidence that it is involved in the biological process: muscle organ development; cell adhesion mediated by integrin; muscle attachment.
19 alleles are reported.
The phenotypes of these alleles are annotated with: tendon cell; dorsal oblique muscle; lateral longitudinal muscle; dorsal acute muscle; embryonic/larval muscle system; ventral longitudinal muscle.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: Concanavalin A-like lectin/glucanase; Concanavalin A-like lectin/glucanase, subgroup; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Thrombospondin, C-terminal; Thrombospondin, type 3 repeat; Thrombospondin, type 3-like repeat.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 12-18 embryonic stages, during late pupal stages.
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