Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CYLD
Flybase description The gene cylindromatosis is referred to in FlyBase by the symbol Dmel\CYLD (CG5603, FBgn0032210).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.2778 -2.2238 -4.330128 -2.7867 -7.103214 -3.6818 -3.09568 -5.762708
    Affimetrix absolute value 6.054 6.47 6.119 6.925 6.02 6.683 6.933 5.835
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: ubiquitin-specific protease activity.
There is experimental evidence that it is involved in the biological process: protein deubiquitination; stress-activated protein kinase signaling cascade; determination of adult lifespan; response to oxidative stress; defense response to bacterium; acylglycerol homeostasis.
15 alleles are reported.
The phenotypes of these alleles are annotated with: adult fat body; lipid particle; scutellum.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Cytoskeleton-associated protein, Gly-rich domain; Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2; Ribosomal protein S3Ae.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 12-18 embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages.
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