Flygut: an atlas of the Drosophila adult midgut

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Gene name Cul-4
Flybase description The gene Cullin-4 is referred to in FlyBase by the symbol Dmel\Cul-4 (CG8711, FBgn0033260).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.9072 1.2085 -1.355698 0.3388 -2.166858 -1.3103 -1.44715 -1.778889
    Affimetrix absolute value 7.531 7.883 7.763 8.398 7.683 8.173 8.026 7.492
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions There is not condition-dependent expression data available for this gene.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity.
There is experimental evidence that it is involved in the biological process: mitotic cell cycle G2/M transition DNA damage checkpoint; eggshell chorion gene amplification; positive regulation of NFAT protein import into nucleus.
12 alleles are reported.
The phenotype of these alleles is annotated with: mesothoracic tergum.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Cullin homology; Cullin protein, neddylation domain; Cullin repeat-like-containing domain; Cullin, N-terminal; Cullin, conserved site; Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.
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