Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Damm
Flybase description The gene Death associated molecule related to Mch2 is referred to in FlyBase by the symbol Dmel\Damm (CG18188, FBgn0033659).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -21.9256 3.438 5.435672 2.2306 5.813549 5.844 -8.65296 4.632811
    Affimetrix absolute value 4.008 9.352 10.602 9.529 11.295 11.099 5.818 10.443
    Affymetric present call in "x" number of chips 0 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity.
There is experimental evidence that it is involved in the biological process: apoptosis; induction of apoptosis.
8 alleles are reported.
The phenotypes of these alleles are annotated with: eye; ommatidium.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 18-24 hour embryonic stages, during late larval stages, during late pupal stages, in stages of adults of both sexes.
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