Flygut: an atlas of the Drosophila adult midgut

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Gene name Eps-15
Flybase description The gene Epidermal growth factor receptor pathway substrate clone 15 is referred to in FlyBase by the symbol Dmel\Eps-15 (CG16932, FBgn0035060).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.5006 -3.5427 -4.492039 -4.2157 -7.13582 -5.6463 -4.87995 -6.243888
    Affimetrix absolute value 5.732 5.812 6.027 6.33 5.961 6.089 6.294 5.663
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding.
There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; synaptic vesicle endocytosis; vesicle-mediated transport; regulation of synaptic growth at neuromuscular junction.
22 alleles are reported.
The phenotypes of these alleles are annotated with: glial cell; eye disc; macrochaeta; bouton; embryonic/larval neuromuscular junction; socket.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand-like domain; EPS15 homology (EH).
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
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