Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CG7447
Flybase description The gene slowdown is referred to in FlyBase by the symbol Dmel\slow (CG7447, FBgn0035539).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.0728 -18.2414 -27.207287 -33.7552 -39.054386 -41.3627 -32.8114 -26.262612
    Affimetrix absolute value 5.625 3.44 3.45 3.319 3.471 3.195 3.52 3.575
    Affymetric present call in "x" number of chips 3 3 2 1 1 1 2 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding.
There is experimental evidence that it is involved in the biological process: muscle attachment.
8 alleles are reported.
The phenotypes of these alleles are annotated with: muscle attachment site; embryonic/larval somatic muscle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; EMI domain; Epidermal growth factor-like; Epidermal growth factor-like, type 3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period.
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