Flygut: an atlas of the Drosophila adult midgut

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Gene name PGRP-LC
Flybase description The gene Peptidoglycan recognition protein LC is referred to in FlyBase by the symbol Dmel\PGRP-LC (CG4432, FBgn0035976).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.258 -1.9683 -3.482242 -3.7694 -6.415889 -3.7128 0.67125 -3.721777
    Affimetrix absolute value 8.079 6.658 6.382 6.493 6.082 6.69 8.933 6.402
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: peptidoglycan receptor activity; protein binding; Gram-negative bacterial cell surface binding; protein dimerization activity; peptidoglycan binding.
There is experimental evidence that it is involved in the biological process: immune response; response to bacterium; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; defense response to Gram-negative bacterium; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response; peptidoglycan recognition protein signaling pathway; defense response to virus; antibacterial humoral response.
37 alleles are reported.
No phenotypic data is available.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: N-acetylmuramoyl-L-alanine amidase domain; Peptidoglycan recognition protein; Peptidoglycan recognition protein family domain, metazoa/bacteria.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed during early pupal stages.
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