Flygut: an atlas of the Drosophila adult midgut

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Gene name Mkp3
Flybase description The gene Mitogen-activated protein kinase phosphatase 3 is referred to in FlyBase by the symbol Dmel\Mkp3 (CG14080, FBgn0036844).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -11.2781 -7.742 -15.092117 -16.3342 -24.478933 -15.6777 -15.57998 -17.230676
    Affimetrix absolute value 4.919 4.693 4.281 4.393 4.207 4.698 4.663 4.162
    Affymetric present call in "x" number of chips 3 3 3 3 1 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: phosphatase activity.
There is experimental evidence that it is involved in the biological process: protein dephosphorylation; primary branching, open tracheal system; cell-cell adhesion; regulation of cell proliferation; imaginal disc-derived wing vein specification; maintenance of epithelial integrity, open tracheal system; mucosal immune response; negative regulation of MAPKKK cascade.
50 alleles are reported.
The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: organ system subdivision; organ system; adult segment; external compound sense organ; thoracic segment; tracheal branch primordium; late extended germ band embryo; peripheral nervous system; dorsal branch primordium; histaminergic neuron.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Dual specificity phosphatase, catalytic domain; Dual specificity phosphatase, subgroup, catalytic domain; Dual specificity protein phosphatase (MAP kinase phosphatase); MAP kinase phosphatase; Protein-tyrosine/Dual-specificity phosphatase; Rhodanese-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, during late pupal stages, in adult female stages.
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