Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Lrrk
Flybase description The gene Leucine-rich repeat kinase is referred to in FlyBase by the symbol Dmel\Lrrk (CG5483, FBgn0038816).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -19.5746 -7.389 -8.882126 -13.4919 -17.281712 -12.9566 -8.9842 -15.915196
    Affimetrix absolute value 4.118 4.735 5.03 4.663 4.672 4.868 5.429 4.375
    Affymetric present call in "x" number of chips 2 3 3 3 3 3 3 2
Intestinal gene expression in different physiological conditions There is not condition-dependent expression data available for this gene.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity; protein kinase activity.
There is experimental evidence that it is involved in the biological process: synapse organization.
16 alleles are reported.
The phenotypes of these alleles are annotated with: NMJ bouton; neuromuscular junction; dopaminergic neuron; type I bouton; mitochondrion.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Leucine-rich repeat; Leucine-rich repeat, typical subtype; Mitochondrial Rho-like; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; ROC GTPase; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain; Small GTPase superfamily; WD40 repeat-like-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.
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