Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Miro
Flybase description The gene Mitochondrial Rho is referred to in FlyBase by the symbol Dmel\Miro (CG5410, FBgn0039140).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.0374 -1.4268 -1.627277 -1.4052 -2.007963 -1.7742 -1.87597 -1.996054
    Affimetrix absolute value 7.387 7.114 7.474 7.902 7.753 7.736 7.681 7.263
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: GTP binding; calcium ion binding; GTPase activity.
There is experimental evidence that it is involved in the biological process: synaptic transmission; mitochondrion localization; synaptic vesicle transport; establishment of mitochondrion localization, microtubule-mediated; microtubule cytoskeleton organization; cytoplasmic microtubule organization.
13 alleles are reported.
The phenotypes of these alleles are annotated with: neuron; dendrite; dorsal multidendritic neuron ddaE; mitochondrion.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Calcium-binding EF-hand; EF hand associated, type-1; EF hand associated, type-2; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand-like domain; MIRO; Mitochondrial Rho-like; Small GTPase superfamily; Small GTPase superfamily, mitochondrial rho type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed during early pupal stages, in adult male stages.
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