Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CG2118
Flybase description This gene is referred to in FlyBase by the symbol Dmel\CG2118 (FBgn0039877).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.2615 -2.2928 -2.72974 -4.0386 -4.479042 -3.4752 -2.70812 -5.022287
    Affimetrix absolute value 6.331 6.438 6.767 6.383 6.606 6.772 7.123 5.97
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: methylcrotonoyl-CoA carboxylase activity.
Based on sequence similarity, it is predicted to be involved in the biological process: leucine metabolic process.
4 alleles are reported.
No phenotypic data is available.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: ATP-grasp fold; ATP-grasp fold, subdomain 1; ATP-grasp fold, subdomain 2; Biotin carboxylase, C-terminal; Biotin carboxylation domain; Biotin-binding site; Biotin/lipoyl attachment; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Pre-ATP-grasp fold; PreATP-grasp-like fold; Rudiment single hybrid motif; Single hybrid motif.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages, in adult female stages.
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