Flygut: an atlas of the Drosophila adult midgut

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Gene name POSH
Flybase description The gene Plenty of SH3s is referred to in FlyBase by the symbol Dmel\POSH (CG4909, FBgn0040294).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.402 -2.7375 -5.315082 -4.8042 -8.948904 -5.4646 -6.13105 -7.563943
    Affimetrix absolute value 6.271 6.176 5.81 6.145 5.633 6.113 5.971 5.473
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: ubiquitin-protein ligase activity.
There is experimental evidence that it is involved in the biological process: protein localization; negative regulation of cell death; determination of adult lifespan; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization; rhabdomere development.
13 alleles are reported.
The phenotypes of these alleles are annotated with: eye; macrochaeta; genitalia; tarsal segment; wing; melanotic mass; wing hair.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Neutrophil cytosol factor 2 p67phox; Src homology-3 domain; Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
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