Flygut: an atlas of the Drosophila adult midgut

 Mouche Logo lab lemaitre Bbcf logo
Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Alk
Flybase description The gene Alk is referred to in FlyBase by the symbol Dmel\Alk (CG8250, FBgn0040505).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -58.3902 -37.8046 -51.069054 -56.79 -69.430317 -70.1297 -72.10946 -58.530515
    Affimetrix absolute value 2.544 2.394 2.518 2.563 2.641 2.432 2.393 2.4
    Affymetric present call in "x" number of chips 0 0 0 1 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: transmembrane receptor protein tyrosine kinase activity.
There is experimental evidence that it is involved in the biological process: visceral muscle development; digestive tract development; activation of MAPKK activity; axon guidance; compound eye photoreceptor development; regulation of hemocyte differentiation; mesoderm development.
26 alleles are reported.
The phenotypes of these alleles are annotated with: embryonic/larval midgut; lamellocyte; visceral mesoderm; embryonic somatic muscle; embryonic/larval digestive system; embryonic myoblast; hemocyte; embryonic visceral muscle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Concanavalin A-like lectin/glucanase; Low-density lipoprotein (LDL) receptor class A repeat; MAM domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, receptor class II, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
.