Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Lag1
Flybase description The gene schlank is referred to in FlyBase by the symbol Dmel\schlank (CG3576, FBgn0040918).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.4365 1.411 1.90335 1.4236 1.238021 1.2342 -2.0912 0.658444
    Affimetrix absolute value 6.648 8.101 9.093 8.883 9.061 8.857 7.493 8.613
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: triglyceride metabolic process; negative regulation of lipid catabolic process; positive regulation of lipid biosynthetic process; SREBP-mediated signaling pathway; ceramide biosynthetic process.
19 alleles are reported.
The phenotype of these alleles is annotated with: trichogen cell.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Homeobox; Homeodomain-like; Homeodomain-related; Longevity assurance, LAG1/LAC1; TRAM/LAG1/CLN8 homology domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages.
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