Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name dome
Flybase description The gene domeless is referred to in FlyBase by the symbol Dmel\dome (CG14226, FBgn0043903).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.1369 -1.3887 -2.628271 -3.8412 -4.852142 -4.2894 -6.45261 -4.007591
    Affimetrix absolute value 6.365 7.171 6.798 6.49 6.567 6.536 5.911 6.267
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: transmembrane receptor activity.
There is experimental evidence that it is involved in the biological process: blastoderm segmentation; morphogenesis of an epithelium; hindgut morphogenesis; border follicle cell migration; positive regulation of cell proliferation; long-term memory; JAK-STAT cascade; open tracheal system development; compound eye morphogenesis.
49 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; organ system subdivision; multicellular structure; spiracle; integumentary specialisation; portion of tissue; adult segment; non-connected developing system; embryonic hindgut; epithelial cell; external compound sense organ.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Fibronectin type III domain; Fibronectin, type III; Immunoglobulin-like fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.
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