Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name pain
Flybase description The gene painless is referred to in FlyBase by the symbol Dmel\pain (CG15860, FBgn0060296).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.438 -3.8496 -11.345408 -6.5164 -9.481213 -5.1538 -2.35614 -8.335874
    Affimetrix absolute value 7.152 5.713 4.69 5.697 5.524 6.206 7.336 5.232
    Affymetric present call in "x" number of chips 3 3 2 3 1 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: calcium channel activity.
There is experimental evidence that it is involved in the biological process: feeding behavior; regulation of heart contraction; sensory perception of pain; response to heat; behavioral response to pain; negative gravitaxis; copulation; regulation of female receptivity.
17 alleles are reported.
The phenotype of these alleles is annotated with: embryonic/larval heart.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Ion transport.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed within 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period.
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