Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Epac
Flybase description The gene Epac is referred to in FlyBase by the symbol Dmel\Epac (CG34392, FBgn0085421).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -40.3582 -21.289 -28.271039 -33.3298 -46.408978 -37.6822 -44.4175 -34.700174
    Affimetrix absolute value 3.074 3.217 3.387 3.333 3.232 3.338 3.077 3.188
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity; Rap guanyl-nucleotide exchange factor activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of protein phosphorylation; regulation of small GTPase mediated signal transduction.
8 alleles are reported.
No phenotypic data is available.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Cyclic nucleotide-binding domain; Cyclic nucleotide-binding-like; DEP domain; Guanine-nucleotide dissociation stimulator CDC25; Ras guanine nucleotide exchange factor; Ras guanine nucleotide exchange factor, domain; Ras guanine-nucleotide exchange factor, conserved site; Ras-association; Ras-like guanine nucleotide exchange factor, N-terminal; RmlC-like jelly roll fold; Winged helix-turn-helix transcription repressor DNA-binding; cAMP/cGMP-dependent protein kinase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period.
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