Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name sif
Flybase description The gene still life is referred to in FlyBase by the symbol Dmel\sif (CG34418, FBgn0085447).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -40.7557 -24.0369 -26.100171 -52.0867 -51.849123 -56.8304 -49.04428 -34.600668
    Affimetrix absolute value 3.061 3.06 3.491 2.695 3.087 2.736 2.936 3.181
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: Rho guanyl-nucleotide exchange factor activity.
There is experimental evidence that it is involved in the biological process: regulation of axonogenesis.
19 alleles are reported.
The phenotypes of these alleles are annotated with: bouton; mesothoracic tergum.
It has 8 annotated transcripts and 8 annotated polypeptides.
Protein features are: Dbl homology (DH) domain; EVH1; Guanine-nucleotide dissociation stimulator, CDC24, conserved site; PDZ/DHR/GLGF; Pleckstrin homology domain; Pleckstrin homology-type; Raf-like Ras-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
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