Flygut: an atlas of the Drosophila adult midgut

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Gene name Sec61alpha
Flybase description The gene Sec61α is referred to in FlyBase by the symbol Dmel\Sec61α (CG9539, FBgn0086357).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 2.7998 16.6062 14.075053 6.0317 5.395834 4.1667 3.10277 8.509879
    Affimetrix absolute value 9.888 11.638 11.927 10.974 11.176 10.618 10.178 11.255
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein transporter activity.
There is experimental evidence that it is involved in the biological process: dorsal closure; cuticle development; head involution; cell death; negative regulation of autophagy.
30 alleles are reported.
The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; midgut constriction 2; cephalopharyngeal skeleton; embryonic/larval midgut primordium; tracheal metamere; embryonic/larval tracheal system; crystal cell; denticle belt; embryonic leading edge cell.
It has one annotated transcript and one annotated polypeptide.
Protein features are: SecY protein; SecY subunit domain; Translocon Sec61/SecY, plug domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.
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