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Gene name | Nedd4 | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Nedd4 is referred to in FlyBase by the symbol Dmel\Nedd4 (CG42279, FBgn0259174). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Notch binding; protein binding; protein domain specific binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; receptor internalization; positive regulation of receptor internalization; axon guidance; positive regulation of synapse assembly; positive regulation of endocytosis; axon midline choice point recognition; protein ubiquitination. 45 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; posterior commissure; wing margin bristle; anterior crossvein; longitudinal connective; presumptive embryonic/larval central nervous system; wing; wing vein; anterior commissure. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; C2 region; HECT; WW/Rsp5/WWP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. . |