Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name crb
Flybase description The gene crumbs is referred to in FlyBase by the symbol Dmel\crb (CG6383, FBgn0259685).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.2838 1.2684 -3.033844 -1.8994 -6.916872 -2.4184 -0.76452 -5.278804
    Affimetrix absolute value 8.052 7.941 6.64 7.488 6.063 7.294 8.104 6.104
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein kinase C binding.
There is experimental evidence for 25 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; cellular process; establishment or maintenance of bipolar cell polarity; sensory organ development; cell junction organization; compound eye photoreceptor development; system development; positive regulation of cell proliferation; gland morphogenesis; embryonic development via the syncytial blastoderm; open tracheal system development; establishment or maintenance of polarity of follicular epithelium; multicellular organism reproduction.
93 alleles are reported.
The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: organ system subdivision; organ system; external compound sense organ; non-connected developing system; adult segment; adherens junction; peripheral nervous system; spiracle; embryonic hindgut; imaginal precursor; late extended germ band embryo.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Concanavalin A-like lectin/glucanase; Concanavalin A-like lectin/glucanase, subgroup; EGF; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Laminin G domain; Laminin G, subdomain 1; Laminin G, subdomain 2.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages.
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