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Gene name | dl | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene dorsal is referred to in FlyBase by the symbol Dmel\dl (CG6667, FBgn0260632). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding; high mobility group box 1 binding; repressing transcription factor binding. There is experimental evidence that it is involved in the biological process: immune response; melanization defense response; peripheral nervous system neuron development; maternal determination of anterior/posterior axis, embryo; regulation of hemocyte proliferation; regulation of alternative nuclear mRNA splicing, via spliceosome; plasmatocyte differentiation. 155 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system subdivision; organ system; adult segment; portion of tissue; multicellular structure; extended germ band embryo; imaginal precursor; epithelial furrow; spiracle; external compound sense organ. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Cell surface receptor IPT/TIG; Immunoglobulin E-set; Immunoglobulin-like fold; NF-kappa-B/Rel/dorsal; Rel homology; p53-like transcription factor, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages. . |