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Gene name | Atg1 | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Autophagy-specific gene 1 is referred to in FlyBase by the symbol Dmel\Atg1 (CG10967, FBgn0260945). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: kinesin binding; protein kinase activity. There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission; regulation of cell growth; nurse cell apoptosis; larval midgut histolysis; synaptic growth at neuromuscular junction; negative regulation of TOR signaling cascade; regulation of autophagy; autophagy; axon cargo transport; synapse organization. 45 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; organ system subdivision; multicellular structure; portion of tissue; anatomical structure; adult; embryonic/larval hemocoel; cytoplasmic part; embryonic/larval fat body; synapse; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase Unc-51; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, C-terminal; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. . |